Psoriasis : Psoriasis a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate. Environmental, genetic, and immunologic factors appear to play a role. The disease most commonly manifests on the skin of the elbows, knees, scalp, lumbosacral areas, intergluteal clefts, and glans penis. In up to 30% of patients, the joints are also affected. Medications used in the management of psoriasis include Topical corticosteroids (eg, triamcinolone acetonide 0.025-0.1% cream, betamethasone 0.025-0.1% cream), Ophthalmic corticosteroids (eg, prednisolone acetate 1% ophthalmic, dexamethasone ophthalmic), Intramuscular corticosteroids (eg, triamcinolone). Coal tar ,Keratolytic agents (eg, anthralin), Vitamin D analogs (eg, calcitriol ointment, calcipotriene, calcipotriene and betamethasone topical ointment) and Topical retinoids (eg, tazarotene aqueous gel and cream 0.05% and 0.1%) are frequently used in the management of Psoriasis. Other choices include Antimetabolites (eg, methotrexate), Immunomodulators (eg, tacrolimus topical 0.1%, cyclosporine, alefacept, ustekinumab), TNF inhibitors (eg, infliximab, etanercept, adalimumab) and Systemic antipsoriatic agents. (eg, ustekinumab)


Inflammation : "A fundamental pathologic process consisting of a dynamic complex of histologically apparent cytologic changes, cellular infiltration, and mediator release that occurs in the affected blood vessels and adjacent tissues in response to an injury or abnormal stimulation caused by a physical, chemical, or biologic agent, including the local reactions and resulting morphologic changes; the destruction or removal of the injurious material; and the responses that lead to repair and healing. Inflammation is the body's attempt at self-protection; the aim being to remove harmful stimuli, including damaged cells, irritants, or pathogens - and begin the healing process. When something harmful or irritating affects a part of our body, there is a biological response to try to remove it, the signs and symptoms of inflammation, specifically acute inflammation, show that the body is trying to heal itself. Inflammation does not mean infection, even when an infection causes inflammation. Infection is caused by a bacterium, virus or fungus, while inflammation is the body's response to it. Acute inflammation - starts rapidly (rapid onset) and quickly becomes severe. Signs and symptoms are only present for a few days, but in some cases may persist for a few weeks. Examples of diseases, conditions, and situations which can result in acute inflammation include: acute bronchitis, infected ingrown toenail, sore throat from a cold or flu, a scratch/cut on the skin, exercise (especially intense training), acute appendicitis, acute dermatitis, acute tonsillitis, acute infective meningitis, acute sinusitis, or a blow. Chronic inflammation - this means long-term inflammation, which can last for several months and even years. It can result from: ? Failure to eliminate whatever was causing an acute inflammation ? An autoimmune response to a self antigen - the immune system attacks healthy tissue, mistaking it (them) for harmful pathogens. ? A chronic irritant of low intensity that persists Examples of diseases and conditions with chronic inflammation include: asthma, chronicpeptic ulcer, tuberculosis, rheumatoid arthritis, chronic periodontitis, ulcerative colitis andCrohn's disease, chronic sinusitis, and chronic active hepatitis cancers, rheumatoid arthritis, atherosclerosis, periodontitis, and hay fever Drugs Used _ NSAID’S ( Aspirin, Ibuprofen, Diclofenac Sodium, Aceclofenac , Acetaminophen) and Corticosteroids ( Both Mineralocorticoids and Glucocorticoids)


Atopic dermatitis : Atopic dermatitis also known as atopic eczema or eczema is a type of dermatitis, an inflammatory, relapsing, non-contagious and itchy skin disorder. People with AD often have dry and scaly skin that spans the entire body, except perhaps the diaper area, and intensely itchy red, splotchy, raised lesions to form in the bends of the arms or legs, face and neck. These lesions then weep, crack, swell and crust over. These lesions are at a heightened risk for bacterial, fungal or viral colonisation. Eczema may affect any area of your skin, but it typically appears on your arms and behind your knees. It tends to flare periodically and then subside. The cause of atopic dermatitis is unknown, but it may result from a combination of inherited tendencies for sensitive skin and malfunction in the body's immune system. Following factors worsen the symptoms of atopic dermatitis- • Exposure to environmental irritants like pollen, mold, dust mites, or animals\ • Dry skin • Exposure to water • Sudden temperature changes • Stress • Cold and dry air in the winter • Colds or flu • Contact with chemicals • Contact with rough materials, like wool • Certain fragrances or dyes added to skin lotions or soaps Medication Topical corticosteroids - methylprednisolone, fluocinolone, clobetasol, betamethason,dexamethasone, prednisone Immuno suppresents - Tacrolimus, Mycophenolate mofetil Antihistamine - Cetrizine


Eczema : Eczema is also known as atopic dermatitis, or atopic eczema (the most common form of eczema). Atopic eczema mainly affects children, but it can continue into adulthood or start later in life. Eczema symptoms include itchy, red, and dry skin caused by inflammation. It’s most commonly found in children, although adults can get it. It is also called atopic dermatitis and is treated with oral medications, steroid creams and light therapy . Drugs used Tacrolimus, Hydrocortisone, Dexamethasone, Prednisone