CABGON 0.5MG TABLET
Cabergoline 0.5 Mg
Intas Pharmaceuticals
Should be taken with food.
Oral: Store at 20-25°C.
Hypersensitivity to ergot derivatives Uncontrolled hypertension
Parkinson's disease : Parkinson's disease (PD also known as idiopathic or primary Parkinsonism, hypokinetic rigid syndrome/HRS, or paralysis agitans) is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain; the cause of this cell death is unknown. Tremor, rigidity, bradykinesia, and postural instability are the cardinal features of Parkinsonism and may be present in any combination. There may also be a mild decline in intellectual function. The tremor of about four to six cycles per second is most conspicuous at rest, is enhanced by emotional stress, and is often less severe during voluntary activity. Although it may ultimately be present in all limbs, the tremor is commonly confined to one limb or to the limbs on one side for months or years before it becomes more generalized. Commonly used drugs in Parkinson disease include Levodopa-Carbidopa combination, Anticholinergics (orphenadrine , procyclidine ,trihexyphenidyl ), Dopamine Agonists( Bromocriptine, Carbergoline, Ropinirole, Pramipexole and Lisuride.), COMT inhibitors (entacapone ,Tolcapone) and MAO-B inhibitors ( rasagiline,selegiline) Hyperprolactinaemia : Hyperprolactinaemia is defined as an elevation of prolactin level above 25ng/ml in women of childbearing age and above 20ng/ml in men and post-menopausal women. It occurs in the Pituitary gland which is located at the base of the hypothalamus. Hyperprolactinaemia is a raised level of prolactin in the blood. This hormone stimulates breast epithelial cell proliferation and induces milk production. The primary action of prolactin is to stimulate lactation. However, excessive production of prolactin leads to infertility and gonadal dysfunction. Prolactin suppresses gonadotrophin-releasing hormone (GnRH), resulting in suppression of ovulation in females and reduced testosterone levels and hypogonadism in males. Medication • Most patients will be treated with a dopamine agonist. Dopamine agonists suppress prolactin in most patients, normalise gonadal function and also stop galactorrhoea. Cabergoline and bromo-criptine are both ergot-based dopamine receptor agonists. Cabergoline is the first-line treatment for prolactinomas as it has greater efficacy in suppressing prolactin secretion.
Dopamine antagonists such as the phenothiazines, butyrophenones,thioxanthenes, and metoclopramide might be expected to reduce the prolactin lowering and the antiparkinsonian effects of cabergolin and domperidone might reduce its prolactin lowering effect. Memantine may enhance the effects of cabergolin. Stimulants of gastrointestinal motility such as macrolide antibacterials or octreotide can increase the bioavailability of cabergolin. Alcohol intolerance was noted in 5 of 73 patients receiving cabergolin 10 to 60 mg daily for the treatment of acromegaly. Two patients who had gastrointestinal adverse effects while taking low doses of cabergolin had a marked reduction in their symptoms and were able to tolerate higher doses when they refrained completely from alcohol. Antibacterials Drowsiness, dystonia, choreoathetoid dyskinesias,and visual hallucinations occurred when josamycin was given to a patient receiving cabergolin. Antifungals
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