DINFLA GEL
Diclofenac
WAN BURRY
Diclofenac is available as a tablet, and liquid-filled capsule, a hard gelatin capsule, an extended-release (long-acting) tablet, a delayed-release (releases medication in the intestine) tablet, and as packets of powder for solution (to be mixed with water) and taken orally. Take tabllets or capsules with meals, milk, or antacids to minimize GI distress. Diclofenac liquid-filled capsules are usually taken 4 times a day and diclofenac hard gelatin capsules are usually taken three times a day on an empty stomach.
Store it at room temperature and away from excess heat and moisture.
Active peptic ulcer Hypersensitivity to diclofenac or other NSAIDs Treatment of perioperative pain in CABG surgery 3rd trimester of pregnancy Topical: Not to be applied onto damaged or non-intact skin
Gastric Ulcer : gastric ulcer, also known as peptic ulcer, stomach ulcer &peptic ulcer disease (PUD) is a distinct breach in the mucosa of the stomach as a result of caustic effects of acid and pepsin in the lumen. Younger patients with ulcer-like symptoms are often treated with antacids or H2 antagonists before EGD is undertaken.Patients who are taking nonsteroidal anti-inflammatories (NSAIDs) may also be prescribed a prostaglandin analogue (Misoprostol) in order to help prevent peptic ulcers, which are a side-effect of the NSAIDs. When H. pylori infection is present, the most effective treatments are combinations of 2 antibiotics (e.g. Clarithromycin, Amoxicillin, Tetracycline, Metronidazole) and 1 proton pump inhibitor(PPI), sometimes together with a bismuth compound. In complicated, treatment-resistant cases, 3 antibiotics (e.g. amoxicillin + clarithromycin + metronidazole) may be used together with a PPI and sometimes with bismuth compound. An effective first-line therapy for uncomplicated cases would be Amoxicillin + Metronidazole + Pantoprazole (a PPI). In the absence of H. pylori, long-term higher dose PPIs are often used. Zollinger–Ellison syndrome : Zollinger-Ellison syndrome is a rare disorder that occurs when one or more tumors form in the pancreas and duodenum. The tumors, called gastrinomas, release large amounts of gastrin that cause the stomach to produce large amounts of acid. Normally, the body releases small amounts of gastrin after eating, which triggers the stomach to make gastric acid that helps break down food and liquid in the stomach. The extra acid causes peptic ulcers to form in the duodenum and elsewhere in the upper intestine. The tumors seen with Zollinger-Ellison syndrome are sometimes cancerous and may spread to other areas of the body. MEDICATION : A class of medications called proton pump inhibitors (PPIs) includes: esomeprazole (Nexium) lansoprazole (Prevacid) pantoprazole (Protonix) omeprazole (Prilosec or Zegerid) dexlansoprazole (Dexilant)GERD : Gastroesophageal reflux disease (GERD), gastro-oesophageal reflux disease (GORD), gastric reflux disease, or acid reflux disease is a chronic symptom of mucosal damage caused by stomach acid coming up from the stomach into the esophagus The treatments for GERD include lifestyle modifications, medications, and possibly surgery. Initial treatment is frequently with a proton-pump inhibitor such as omeprazole.
Not to be given IV to patients who are receiving other NSAIDs or anticoagulants including low dose heparin. Renal function may be worsened when used with ciclosporin or triamterene. Altered absorption when given with sucralfate, colestyramine or colestipol. Ophthalmic application of diclofenac may reduce the efficacy of ophthalmic acetylcholine and carbachol. Increased risk of GI ulceration and bleeding when used with corticosteroids, aspirin or anticoagulants. Potentially fatal: Increases blood levels of digoxin, lithium and methotrexate. Potentiate potassium-sparing diuretics.
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