Eptus
EPLERENONE
Glenmark Pharmaceuticals Limited
It available as a tablet taken orally, with or without food.
Store it at room temperature (25°C).
Severe kidney or liver problem Co-administration with ketoconazole ,itraconazole, serum potassium greater than 5.5 mEq/L Type 2 diabetes with microalbuminuria
Schizophrenia : Schizophrenia is a mental disorder characterized by a breakdown in thinking and poor emotional responses. Common symptoms include delusions, such as paranoia; hearing voices or noises that are not there; disorganized thinking; a lack of emotion and a lack of motivation. Drugs Used Aripiprazole , Clozapine, Iloperidone, Ziprasidone, Paliperidone, Lurasidone, Loxapine, Thioridazine, Risperidone, Asenapine, Quetiapine , Trifluoperazine and Psychosis : .
Concomitant use with CYP3A4 Inhibitors (e.g. ketoconazole, voriconazole, itraconazole, fluconazole, clarithromycin, diltiazem saquinavir, verpamil, ritonavir) may increase serum concentrations of Eplerenone. CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenytoin, phenobarbital) may decrease Eplerenone efficacy. Eplerenone may enhance hyperkalaemic effect of ACE inhibitors, angiotensin II receptor blockers, potassium-sparing diuretics or potassium salts. Concomitant use with diazoxide, MAOIs, pentoxifylline, prostacyclin analogues may enhance hypotensive effect of antihypertensives. NSAIDs may possibly reduce the antihypertensive and/or diuretic effects of potassium-sparing diuretics and may increase risk of hyperkalaemia. Lithium toxicity has been reported when used with ACE inhibitors or diuretics; monitor lithium levels when used with Eplerenone.
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It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.