GALVUS-MET
Vildagliptin, metformin hydrochloride
Novartis India Limited
It is available as a tablet taken orally, with food.
Store protected from light and moisture.
Renal impairment (withdraw if renal impairment suspected withdraw if tissue hypoxia likely (for example sepsis, respiratory failure, recent myocardial infarction, hepatic impairment) Use of iodine-containing X-ray contrast media (do not restart metformin until renal function returns to normal) and use of general anaesthesia (suspend metformin 2 days beforehand and restart when renal function returns to normal) Alcohol dependence Pregnancy Anaemia Ketosis
Depression : Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, feelings and sense of well-being In general the type of treatment includepsychotherapy and/or antidepressants, alternative therapies, or active intervention. The most important classes of antidepressants are the selective serotonin reuptake inhibitors (SSRIs), serotonin–norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs). Other drugs used or proposed for the treatment of depression include buprenorphine,tryptophan,low-dose antipsychotics,and St John's wort.
Additive effect with sulphonylureas. Glycaemic control may be affected by diuretics, corticosteroids, phenothiazines, thyroid products, oestrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, chlorpromazine and isoniazid. Metformin effects may be increased by ACE inhibitors, disopyramide, MAOIs. Cimetidine may increase the serum levels of metformin. Concurrent use with contrast agents may increase the risk of metformin-induced lactic acidosis. May decrease the anticoagulant effect of phenprocoumon, therefore routine anticoagulant monitoring is recommended. Potentially fatal: Lactic acidosis with alcohol. Thrombocytopenia has been reported with ketotifen.
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It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.