Gaticin Conc. INJ
GATIFLOXACIN
Not Available
It may be taken with or without food.
NA
Hypersensitivity Children <18 yr; concurrent use of class IA or III antiarrhythmics QT-prolongation drug Diabetics Pregnancy Lactation.
Tuberculosis : Definition: It is a chronic granulomatous infection caused by the bacterium mycobacterium tuberculae Pathogenesis: It is a chronic granulomatous infection caused mainly by the inhalation of tubercular bacilli. The bacilli enters the lungs and get deposited on the upper lobe of the lungs there it forms a primary complex. Once this complex is formed the disease spread through the lymphatic vessel to the adjacent organs or locally. Drugs: First line drugs: Isoniazid, Rifampicin, ethambutol and Pyrizanamide Second line drugs: Aminoglycosides like Amikacin, kanamycin. Polypeptides like capreomycin. Fluoroquinolones like ciprofloxacin, levofloxacin, moxifloxacin Thioamides like ethionamide, prothionamide Cycloserine Para aminosalicylic acid Third line drugs : Rifabutin Macrolides like clarythromycin Linezolid Thioacetazone Vitamin D Thioridazine
Antacids, ferrous salts, bismuth subsalicylate, sucralfate and zinc salts reduce bioavailability of gatifloxacin. May increase digoxin plasma levels. Probenecid, cimetidine and loop diuretics increase gatifloxacin levels. NSAIDs may increase the risk of CNS stimulation and convulsions. Concurrent use of bepridil, cisapride, erythromycin, pentamidine, phenothiazines, or TCAs may prolong QT interval. Concurrent corticosteroid therapy may increase the risk of tendon rupture. Increased risk of hypoglycaemia when used with oral antidiabetic agents. May enhance hypoprothrombinaemic effects of oral anticoagulants.
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It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.