Pneumonia : Pneumonia is an inflammatory condition of the lung affecting primarily the microscopic air sacs known as alveoli. It is usually caused by infection with viruses or bacteria and less commonly other microorganisms, certain drugs and other conditions such as autoimmune diseases. Typical symptoms include a cough, chest pain, fever, and difficulty breathing.
Patients with pneumonia are treated with amoxicillin, doxycycline, clarithromycin or oral macrolide antibiotics (azithromycin, clarithromycin, or erythromycin).Patients with other serious illnesses, such as heart disease, chronic obstructive pulmonary disease, or emphysema, kidney disease, or diabetes are often given more powerful and/or higher dose antibiotics like third- and fourth-generation cephalosporins, carbapenems, fluoroquinolones, aminoglycosides, and vancomycin. In addition to antibiotics, treatment includes: proper diet and oxygen to increase oxygen in the blood when needed. In some patients, medication to ease chest pain and to provide relief from violent cough may be necessary.
Malaria : Malaria is a mosquito-borne disease caused by a parasite. People with malaria often experience fever, chills, and flu-like illness. Left untreated, they may develop severe complications and die. In 2010 an estimated 219 million cases of malaria occurred worldwide and 660,000 people died, most (91%) in the African Region
Quinine derivatives /Quinine sulphate:
Destroys the asexual forms of Plasmodium in three days.
Used in the treatment of cerebral malaria, it clears the clogs in the brain capillaries caused by Plasmodium falciparum.
Not toxic in recommended dosage but excessive dosage may cause temporary deafness.
Pregnant women should not be given quinine derivatives.
Acridine derivatives/Mepacrine and Quinacrine:
Destroys the asexual forms of plasmodium after the third or fourth day.
Toxic effects are temporary yellow coloration of skin, face, eyes and urine.
Biguanie/Paludrine:
Destroys the tissue forms and can be used as a prophylactic drug.
- Prophylactic dosage – 300 mgs once a week
- For treatment – 300 mgs daily for 5 to 10 days
Leprosy : Leprosy is a disease that has been known since biblical times. It causes skin sores, nerve damage, and muscle weakness that gets worse over time. Leprosy is a disease caused by the bacteria Mycobacterium leprae, which causes damage to the skin and the peripheral nervous system. The disease develops slowly (from six months to 40 years!) and results in skin lesions and deformities, most often affecting the cooler places on the body (for example, eyes, nose, earlobes, hands, feet, and testicles). The skin lesions and deformities can be very disfiguring and are the reason that infected individuals historically were considered outcasts in many cultures. Although human-to-human transmission is the primary source of infection, three other species can carry and (rarely) transfer M. leprae to humans: chimpanzees, mangabey monkeys, and nine-banded armadillos. The disease is termed a chronic granulomatous disease, similar to tuberculosis, because it produces inflammatory nodules (granulomas) in the skin and nerves over time.
Cause
• Leprosy is caused by the bacterium Mycobacterium leprae. It is not very contagious and it has a long incubation period (time before symptoms appear), which makes it hard to know where or when someone caught the disease. Children are more likely than adults to get the disease.
• Leprosy has two common forms: tuberculoid and lepromatous. Both forms produce sores on the skin. However, the lepromatous form is most severe. It causes large lumps and bumps (nodules).
Symptoms
Symptoms include:
• Skin lesions that are lighter than your normal skin color
o Lesions have decreased sensation to touch, heat, or pain
o Lesions do not heal after several weeks to months
• Muscle weakness
• Numbness or lack of feeling in the hands, arms, feet, and legs
Treatment
• A number of different antibiotics (including dapsone, rifampin, clofazamine, fluoroquinolones, macrolides, and minocycline) are used to kill the bacteria that cause the disease. More than one antibiotic is often given together.
• Aspirin, prednisone, or thalidomide is used to control inflammation.