MALCIDAL FORTE 50MG/1000MG TABLET
Pyrimethamine50 mg,Sulphadoxine1000 mg
Lark Laboratories Ltd
Pyrimethamine may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
Store pyrimethamine at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light.
Folate deficiency anaemia Epilepsy Pregnancy; especially, during the first trimester due to the possible detrimental effects an antifolate like pyrimethamine might have on organogenesis.
Malaria : Malaria is a mosquito-borne disease caused by a parasite. People with malaria often experience fever, chills, and flu-like illness. Left untreated, they may develop severe complications and die. In 2010 an estimated 219 million cases of malaria occurred worldwide and 660,000 people died, most (91%) in the African Region Quinine derivatives /Quinine sulphate: Destroys the asexual forms of Plasmodium in three days. Used in the treatment of cerebral malaria, it clears the clogs in the brain capillaries caused by Plasmodium falciparum. Not toxic in recommended dosage but excessive dosage may cause temporary deafness. Pregnant women should not be given quinine derivatives. Acridine derivatives/Mepacrine and Quinacrine: Destroys the asexual forms of plasmodium after the third or fourth day. Toxic effects are temporary yellow coloration of skin, face, eyes and urine. Biguanie/Paludrine: Destroys the tissue forms and can be used as a prophylactic drug. - Prophylactic dosage – 300 mgs once a week - For treatment – 300 mgs daily for 5 to 10 days
Antidiabetics Artemether Chlorpromazine Co-trimoxazole Dapsone Folate antagonists Halofantrine Hypoglycaemic agents Mefloquine Sulfafurazole Sulfamethoxazole/Trimethoprim Sulfisoxazole Sulfonamides Sulphonamides Trimethoprim Trimethoprim/Sulfamethoxazole Zidovudine
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It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.