brand name : MEXATE

Generic name : Methotrexate

Basic Info

Use of Drug

Carcinoma of the breast, head and neck and lung

Trophoblastic tumours

Acute lymphoblastic leukaemia

Meningeal leukaemia

Non-Hodgkin’s lymphomas

Advanced cases of mycosis fungoides

Non-metastatic osteosarcoma

Severe rheumatoid arthritis

Category Of Drug

Antimetabolites

Side Effects

CNS- Dizziness, fatigue, headache, language disorder, weakness, paresis, convulsions, destruction of the myelin sheaths (IV after cranio spinal irradiation), inflammation of the arachnoid (a covering of the brain), transient paresis, nerve damage.

	Skin- Redness of the skin, rashes, itching, loss of hair, hives, photosensitivity, pigmentary changes, skin discoloration, dilatation of blood vessels, acne, furunculosis, aggravation of psoriasis by ultraviolet light, severe allergic reactions. 

	Eye and ENT- Blurred vision, inflammation of the gums, inflammation of pharynx. 

	Gastrointestinal- Nausea, vomiting, enteritis, mouth ulcer, diarrhea, abdominal distress (common), loss of appetite, blood in vomit, blood in stool, GI ulceration and bleeding. 

	Genitourinary- Renal failure, blood contains excess amount nitrogen, inflammation of the urinary bladder, blood in urine, severe kidney disease, reproductive disorders, infertility, abortion, fetal defects.

Drug Dose Information

Oral
Severe active rheumatoid arthritis: 
7.5 mg once weekly, adjusted according to response

Intramuscular, subcutaneous or intravenous route in severe attack under expert medical supervision at a dose of 7.5 mg once weekly.

Precautions

Monitor throughout treatment including Blood counts and hepatic and renal function tests
Renal and hepatic impairment 
Reduce dose or withdraw if acute infection develops for woman or man
During contraception and for at least 6 months after treatment
Peptic ulceration
Ulcerative colitis
Diarrhoea
Ulcerative stomatitis
Advise patient to avoid self-medication with salicylates or other
NSAIDs
Warn patient with rheumatoid arthritis to report cough or dyspnoea

Brand Information

Brand Name	MEXATE
Contains	Methotrexate
Manufacturer Name	Zydus Cadila Healthcare Ltd. (German Remedies)

Brand Specifications
	Unit	Quantity	Price	Type
1	10's	1Strip	27.8800	Tablet

How To Take

It available as a tablet taken orally, with or without food.It also available as a solution for injection to be administered by a healthcare provide into a large muscle.

Storage

Store intact vials at room temperature (15-25ï¿½C). Keep this medication in an airtight container.

Contra Indications

Lactation Pregnancy Immunodeficiency syndromes Significant pleural effusion or ascites

Allergic rhinitis : Allergic rhinitis is an allergic inflammation of the nasal airways. It occurs when an allergen, such as pollen, dust, or animal dander (particles of shed skin and hair) is inhaled by an individual with a sensitized immune system. In such individuals, the allergen triggers the production of the antibody immunoglobulin E (IgE), which binds to mast cells and basophils containing histamine.Allergic rhinitis caused by pollens commonly called hay fever or seasonal allergy. Drugs Used (1) ANTIHISTAMINES - Azelastine Hydrochloride (2) CORTICOSTEROIDS - Beclometasone, Betamethasone,Budesonide,Fflunisolide,Fluticasone, Mometasone, and Triamcinolone (3) DECONGESTANTS - Cromoglicate

Allergic rhinitis : Allergic rhinitis is an allergic inflammation of the nasal airways. It occurs when an allergen, such as pollen, dust, or animal dander (particles of shed skin and hair) is inhaled by an individual with a sensitized immune system. In such individuals, the allergen triggers the production of the antibody immunoglobulin E (IgE), which binds to mast cells and basophils containing histamine.Allergic rhinitis caused by pollens commonly called hay fever or seasonal allergy. Drugs Used (1) ANTIHISTAMINES - Azelastine Hydrochloride (2) CORTICOSTEROIDS - Beclometasone, Betamethasone,Budesonide,Fflunisolide,Fluticasone, Mometasone, and Triamcinolone (3) DECONGESTANTS - Cromoglicate

Allergic rhinitis : Allergic rhinitis is an allergic inflammation of the nasal airways. It occurs when an allergen, such as pollen, dust, or animal dander (particles of shed skin and hair) is inhaled by an individual with a sensitized immune system. In such individuals, the allergen triggers the production of the antibody immunoglobulin E (IgE), which binds to mast cells and basophils containing histamine.Allergic rhinitis caused by pollens commonly called hay fever or seasonal allergy. Drugs Used (1) ANTIHISTAMINES - Azelastine Hydrochloride (2) CORTICOSTEROIDS - Beclometasone, Betamethasone,Budesonide,Fflunisolide,Fluticasone, Mometasone, and Triamcinolone (3) DECONGESTANTS - Cromoglicate

Interactions

Acitretin : plasma concentration of methotrexate increased by acitretin . Aspirin : excretion of methotrexate reduced by aspirin Ciclosporin : risk of toxicity when methotrexate given with ciclosporin Cisplatin: increased pulmonary toxicity when methotrexate given with cisplatin Corticosteroids :increased risk of haematological toxicity when methotrexate given with corticosteroids Diclofenac :excretion of methotrexate reduced by diclofenac

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drug’s Side effects

It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.

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brand name : MEXATE

Generic name : Methotrexate

Basic Info

Use of Drug

Category Of Drug

Side Effects

Drug Dose Information

Precautions

Brand Information

How To Take

Storage

Contra Indications

Diseases

Interactions

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brand name : MEXATE

Generic name : Methotrexate

Basic Info

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