Psoriasis : Psoriasis a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate. Environmental, genetic, and immunologic factors appear to play a role. The disease most commonly manifests on the skin of the elbows, knees, scalp, lumbosacral areas, intergluteal clefts, and glans penis. In up to 30% of patients, the joints are also affected.
Medications used in the management of psoriasis include Topical corticosteroids (eg, triamcinolone acetonide 0.025-0.1% cream, betamethasone 0.025-0.1% cream), Ophthalmic corticosteroids (eg, prednisolone acetate 1% ophthalmic, dexamethasone ophthalmic), Intramuscular corticosteroids (eg, triamcinolone). Coal tar ,Keratolytic agents (eg, anthralin), Vitamin D analogs (eg, calcitriol ointment, calcipotriene, calcipotriene and betamethasone topical ointment) and Topical retinoids (eg, tazarotene aqueous gel and cream 0.05% and 0.1%) are frequently used in the management of Psoriasis. Other choices include Antimetabolites (eg, methotrexate), Immunomodulators (eg, tacrolimus topical 0.1%, cyclosporine, alefacept, ustekinumab), TNF inhibitors (eg, infliximab, etanercept, adalimumab) and Systemic antipsoriatic agents. (eg, ustekinumab)
Seborrheic Dermatitis : Symptoms
Seborrheic dermatitis can occur on different body areas. Usually it forms where the skin is oily or greasy. Common areas include the scalp, eyebrows, eyelids, creases of the nose, lips, behind the ears, in the outer ear, and middle of the chest.
In general, symptoms of seborrheic dermatitis include:
• Skin lesions
• Plaques over large area
• Greasy, oily areas of skin
• Skin scales -- white and flaking, or yellowish, oily, and sticky dandruff
• Itching -- may become more itchy if infected
• Mild redness
• Hair loss
Treatment
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• Flaking and dryness can be treated with over-the-counter dandruff or medicated shampoos. You can buy these at the drugstore without a prescription. Look for a product that says on the label it treats seborrheic dermatitis. Such products contain ingredients such as salicylic acid, coal tar, zinc, resorcin, ketoconazole, or selenium sulfide. Use the shampoo according to label instructions.
• Shampoos or lotions containing selenium, ketoconazole, or corticosteroids may be prescribed for severe cases. To apply shampoos, part the hair into small sections, apply to a small area at a time, and massage into the skin. If on face or chest, apply medicated lotion twice per day. Recently, creams classified as topical immune modulators are being used.
• For severe cases, your health care provider will likely prescribe a shampoo or lotion containing a stronger dose of selenium sulfide, ketoconazole, or corticosteroid. A cream that contains an immunomodulator may be prescribed. This medicine suppresses the immune system to treat inflammation.