PROVEND
Proguanil
Not Available
t available as a tablet to take by mouth (orally), with food.
Store it in an airtight container; keep away from children and pets.
Contraindicated in patients with hypersensitivity Severe kidney failure
Malaria : Malaria is a mosquito-borne disease caused by a parasite. People with malaria often experience fever, chills, and flu-like illness. Left untreated, they may develop severe complications and die. In 2010 an estimated 219 million cases of malaria occurred worldwide and 660,000 people died, most (91%) in the African Region Quinine derivatives /Quinine sulphate: Destroys the asexual forms of Plasmodium in three days. Used in the treatment of cerebral malaria, it clears the clogs in the brain capillaries caused by Plasmodium falciparum. Not toxic in recommended dosage but excessive dosage may cause temporary deafness. Pregnant women should not be given quinine derivatives. Acridine derivatives/Mepacrine and Quinacrine: Destroys the asexual forms of plasmodium after the third or fourth day. Toxic effects are temporary yellow coloration of skin, face, eyes and urine. Biguanie/Paludrine: Destroys the tissue forms and can be used as a prophylactic drug. - Prophylactic dosage – 300 mgs once a week - For treatment – 300 mgs daily for 5 to 10 days
May reduce bioavailability of cloxacillin. Absorption is reduced when used with magnesium trisilicate. Increased risk of mouth ulcers when used with chloroquine. Fluvoxamine may reduce the metabolism of proguanil to its active metabolite, cycloguanil. Proguanil may interact with dicumarol, warfarin, typhoid vaccine, chloroquine and aurothioglucose.
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It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.