Psoriasis : Psoriasis a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate. Environmental, genetic, and immunologic factors appear to play a role. The disease most commonly manifests on the skin of the elbows, knees, scalp, lumbosacral areas, intergluteal clefts, and glans penis. In up to 30% of patients, the joints are also affected.
Medications used in the management of psoriasis include Topical corticosteroids (eg, triamcinolone acetonide 0.025-0.1% cream, betamethasone 0.025-0.1% cream), Ophthalmic corticosteroids (eg, prednisolone acetate 1% ophthalmic, dexamethasone ophthalmic), Intramuscular corticosteroids (eg, triamcinolone). Coal tar ,Keratolytic agents (eg, anthralin), Vitamin D analogs (eg, calcitriol ointment, calcipotriene, calcipotriene and betamethasone topical ointment) and Topical retinoids (eg, tazarotene aqueous gel and cream 0.05% and 0.1%) are frequently used in the management of Psoriasis. Other choices include Antimetabolites (eg, methotrexate), Immunomodulators (eg, tacrolimus topical 0.1%, cyclosporine, alefacept, ustekinumab), TNF inhibitors (eg, infliximab, etanercept, adalimumab) and Systemic antipsoriatic agents. (eg, ustekinumab)
Inflammatory bowel disease (IBD) : Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis
TREATMENT
Mesalazine is used to treat Ulcerative colitis, Antibiotics are used in Crohn’s disease and Surgery is used in Crohn’s disease and Ulcerative colitis.
Generally, depending on the level of severity, IBD may require immunosuppression to control the symptom, such as prednisone, TNF inhibition, azathioprine (Imuran), methotrexate, or 6-mercaptopurine.