Ributin
RIFABUTIN
Lupin Limited
It available as a capsule to take by mouth, with food.
Store it at room temperature and away from light.
Hypersensitivity.
Tuberculosis : Definition: It is a chronic granulomatous infection caused by the bacterium mycobacterium tuberculae Pathogenesis: It is a chronic granulomatous infection caused mainly by the inhalation of tubercular bacilli. The bacilli enters the lungs and get deposited on the upper lobe of the lungs there it forms a primary complex. Once this complex is formed the disease spread through the lymphatic vessel to the adjacent organs or locally. Drugs: First line drugs: Isoniazid, Rifampicin, ethambutol and Pyrizanamide Second line drugs: Aminoglycosides like Amikacin, kanamycin. Polypeptides like capreomycin. Fluoroquinolones like ciprofloxacin, levofloxacin, moxifloxacin Thioamides like ethionamide, prothionamide Cycloserine Para aminosalicylic acid Third line drugs : Rifabutin Macrolides like clarythromycin Linezolid Thioacetazone Vitamin D Thioridazine
May reduce efficacy of oral contraceptives and other cytochrome P450 enzyme metabolised medicines. May decrease serum levels and efficacy of antidiabetics such as tolbutamide, gliclazide and glibenclamide. May decrease serum levels of atovaquone and delavirdine. Serum levels may be increased by azole antifungals. May increase clearance of dapsone. Bioavailability may be increased by protease inhibitors. Absorption may be decreased when given with antacids, anticholinergics and opioids.
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It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.