Asthma : According to WHO - Asthma attacks all age groups but often starts in childhood. It is a disease characterized by recurrent attacks of breathlessness and wheezing, which vary in severity and frequency from person to person. In an individual, they may occur from hour to hour and day to day.
This condition is due to inflammation of the air passages in the lungs and affects the sensitivity of the nerve endings in the airways so they become easily irritated. In an attack, the lining of the passages swell causing the airways to narrow and reducing the flow of air in and out of the lungs.
Classification of drugs
1. Bronchodialators
A. Sympathomimetics : Adrenaline, Ephedrine, Isoprenaline, Salbutamol, Terbutaline, Bambuterol, Salmetrol, Formoterol.
B. Methylxanthines : Theophylline, Aminophylline, Hydroxyethyl theophylline.
C. Anticholinergics: Atropine, Ipratropium bromide
2. Leukotrienne antagonis - Montelukast, Zafirlukast
3. Mast cell stabilizers : Sodium cromglycate, Nedocromil,Krtotifen.
4. Corticosteroids : a) Systemic : Hydrocortisone, Prednisolone and others
b) Inhalational : Beclomethasone dipropionate, Budesonide, Flunisolide
Allergic rhinitis : Allergic rhinitis is an allergic inflammation of the nasal airways. It occurs when an allergen, such as pollen, dust, or animal dander (particles of shed skin and hair) is inhaled by an individual with a sensitized immune system. In such individuals, the allergen triggers the production of the antibody immunoglobulin E (IgE), which binds to mast cells and basophils containing histamine.Allergic rhinitis caused by pollens commonly called hay fever or seasonal allergy.
Drugs Used
(1) ANTIHISTAMINES - Azelastine Hydrochloride
(2) CORTICOSTEROIDS - Beclometasone, Betamethasone,Budesonide,Fflunisolide,Fluticasone, Mometasone, and Triamcinolone
(3) DECONGESTANTS - Cromoglicate
Hay fever : Allergic rhinitis caused by grass pollens, it is known as hay fever.
Treatment
Antihistamines
Antihistamine drugs can be taken orally and nasally to control symptoms such as sneezing, rhinorrhea, itching, and conjunctivitis.
Steroids
Intranasal corticosteroids are used to control symptoms associated with sneezing, rhinorrhea, itching, and nasal congestion.
Other
Other measures that may be used second line include: decongestants, cromolyn, leukotriene receptor antagonists, and nonpharmacologic therapies such as nasal irrigation
Eczema : Eczema is also known as atopic dermatitis, or atopic eczema (the most common form of eczema). Atopic eczema mainly affects children, but it can continue into adulthood or start later in life. Eczema symptoms include itchy, red, and dry skin caused by inflammation. It’s most commonly found in children, although adults can get it. It is also called atopic dermatitis and is treated with oral medications, steroid creams and light therapy .
Drugs used
Tacrolimus, Hydrocortisone, Dexamethasone, Prednisone
Psoriasis : Psoriasis a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate. Environmental, genetic, and immunologic factors appear to play a role. The disease most commonly manifests on the skin of the elbows, knees, scalp, lumbosacral areas, intergluteal clefts, and glans penis. In up to 30% of patients, the joints are also affected.
Medications used in the management of psoriasis include Topical corticosteroids (eg, triamcinolone acetonide 0.025-0.1% cream, betamethasone 0.025-0.1% cream), Ophthalmic corticosteroids (eg, prednisolone acetate 1% ophthalmic, dexamethasone ophthalmic), Intramuscular corticosteroids (eg, triamcinolone). Coal tar ,Keratolytic agents (eg, anthralin), Vitamin D analogs (eg, calcitriol ointment, calcipotriene, calcipotriene and betamethasone topical ointment) and Topical retinoids (eg, tazarotene aqueous gel and cream 0.05% and 0.1%) are frequently used in the management of Psoriasis. Other choices include Antimetabolites (eg, methotrexate), Immunomodulators (eg, tacrolimus topical 0.1%, cyclosporine, alefacept, ustekinumab), TNF inhibitors (eg, infliximab, etanercept, adalimumab) and Systemic antipsoriatic agents. (eg, ustekinumab)