SOLONEX DT 100MG TABLET
Isoniazid 100 mg
Macleods Pharmaceuticals Limited
It comes as a tablet and liquid to take by mouth, on an empty stomach.
Store it at room temperature, away from light and excess heat. Do not allow the liquid to freeze.
Drug-induced Hepatic Disease.
Tuberculosis : Definition: It is a chronic granulomatous infection caused by the bacterium mycobacterium tuberculae Pathogenesis: It is a chronic granulomatous infection caused mainly by the inhalation of tubercular bacilli. The bacilli enters the lungs and get deposited on the upper lobe of the lungs there it forms a primary complex. Once this complex is formed the disease spread through the lymphatic vessel to the adjacent organs or locally. Drugs: First line drugs: Isoniazid, Rifampicin, ethambutol and Pyrizanamide Second line drugs: Aminoglycosides like Amikacin, kanamycin. Polypeptides like capreomycin. Fluoroquinolones like ciprofloxacin, levofloxacin, moxifloxacin Thioamides like ethionamide, prothionamide Cycloserine Para aminosalicylic acid Third line drugs : Rifabutin Macrolides like clarythromycin Linezolid Thioacetazone Vitamin D Thioridazine
May increase toxicity of carbamazepine, ethosuximide, phenytoin, diazepam and triazolam, chlorzoxazone, theophylline, clofazimine, cycloserine and warfarin. May increase metabolism of enflurane resulting in nephrotoxic fluoride levels. Reduced efficacy and increased risk of peripheral neuropathies and hepatotoxicity with alcohol. Reduced absoprtion with aluminium-containing antacids; give at least 1 hr before the antacid. Decreased serum levels with ketoconazole, zalcitabine. Increased risk of peripheral neuropathy with stavudine and zalcitabine. Decreased serum levels if taken with food. Avoid tyramine-containing foods e.g. cheese, red wine and some fish as severe elevations in BP may occur.
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It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.