brand name : Spreadase

Generic name : Hyaluronidase

Basic Info

Use of Drug

Adjuvent to increase absorption and disperse of other injected drugs

Adjuvent to increase absorption rate of fluids given by hypodermoclysis.

Adjuvent in excretary urography.

Category Of Drug

Protein enzyme

Side Effects

Common side effects are:

Redness or pain at the injection site.

Severse side effects are:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness).

Drug Dose Information

Adult: SC- The recommended dose is 1,500 u for every 500-1,000 mL of fluid for SC administration.

Management of I.V. extravasation:
Reconstitute the 150 unit vial of lyophilized powder with 1 mL normal saline; take 0.1 mL of this solution and dilute with 0.9 mL normal saline to yield 15 units/mL; using a 25- or 26-gauge needle, five 0.2 mL injections are made subcutaneously or intradermally into the extravasation site at the leading edge, changing the needle after each injection.

Hypodermoclysis:
S.C.: 1 mL (150 units) is added to 1000 mL of infusion fluid and 0.5 mL (75 units) in injected into each clysis site at the initiation of the infusion.

I.V.: 15 units is added to each 100 mL of I.V. fluid to be administered
Children <3 years: Limit volume of single clysis to 200 mL
Premature Infants: Do not exceed 25 mL/kg/day and not >2 mL/minute
Adults: Absorption and dispersion of drugs: 150 units are added to the vehicle containing the drug.

Precautions

History of impaired kidney function
Infections
During pregnancy and breastfeeding

Brand Information

Brand Name	Spreadase
Contains	HYALURONIDASE
Manufacturer Name	Not Available

Brand Specifications
	Unit	Quantity	Price	Type
1	1500000 IU x VIAL	0	0.0000	Injection
2	1500 IU	5	225.0000	Injection
3	750000 IU	1 ml	255.0000	Injection

How To Take

It available as a solution for injection, to be administered by a healthcare under the skin.

Storage

Store unopened vials of powder for injection in refrigerator (36° to 46°F). After reconstitution, store at controlled room temperature (68° to 77°F) and use within 6 h.

Interactions

Antihistamines Corticotropin Cortisone, Estrogens Salicylates

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drug’s Side effects

It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.

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brand name : Spreadase

Generic name : Hyaluronidase

Basic Info

Use of Drug

Category Of Drug

Side Effects

Drug Dose Information

Precautions

Brand Information

How To Take

Storage

Contra Indications

Diseases

Interactions

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drug’s Side effects

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brand name : Spreadase

Generic name : Hyaluronidase

Basic Info

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