Paget's disease of bone : Paget disease is a localized disorder of bone remodeling that typically begins with excessive bone resorption followed by an increase in bone formation. This osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone.Individuals with Paget's disease experience rapid isolated bone repair, which causes a variety of symptoms from softer bones to enlarged bone growth, typically involving one or more bones of the pelvis, low back (spine), hips, thighs, head (skull) and arms. Medical therapies have proven effective in reducing the frequency of pain, fractures and arthritis that may be caused by this condition.
Medications that help reduce the pain associated with Paget's include acetaminophen and anti-inflammatory drugs such as ibuprofen and naproxen. In addition, bisphosphonates reduce the pain and help the body regulate the bone-building process to stimulate more normal bone growth. Alendronate , Etidronate, Risedronate to be taken orally.There are also injectable medications. Injectable medications that can be given for Paget's include Pamidronate which is injected in the vein once a month or once every few months. Zoledronic acid which is injected in the vein once a year. Calcitonin, a hormone that is injected under the skin several times a week.Surgery for arthritis caused from Paget's disease is effective in reducing pain and improving function.Medical treatment is not expected to correct some of the changes of the Paget's disease that have already occurred, such as hearing loss, deformity or osteoarthritis.
Osteoporosis : Osteoporosis causes bones to become weak and brittle — so brittle that a fall or even mild stresses like bending over or coughing can cause a fracture. Osteoporosis-related fractures most commonly occur in the hip, wrist or spine. Bone is living tissue, which is constantly being absorbed and replaced. Osteoporosis occurs when the creation of new bone doesn't keep up with the removal of old bone.
Symptoms
Signs and symptoms include:
• Back pain, caused by a fractured or collapsed vertebra
• Loss of height over time
• A stooped posture
• A bone fracture that occurs much more easily than expected
Treatments
For both men and women, the most widely prescribed osteoporosis medications are bisphosphonates. Examples include:
• Alendronate (Fosamax, Binosto)
• Risedronate (Actonel, Atelvia)
• Ibandronate (Boniva)
• Zoledronic acid (Reclast, Zometa)