brand name : ZAVINEX

Generic name : Interferon Alfa-2a

Basic Info

Use of Drug

Antineoplastic
Immunomodulatory
Antiviral Agents

Category Of Drug

Antiviral/ Immunological Chemotherapy

Side Effects

Depressive illness, suicidal behaviour, irritability, insomnia, anxiety. 
Flu-like symptoms.
Headache, dizziness, paraesthesia, confusion, impaired concentration, alteration in taste or smell
GI disturbances
Dryness of oropharynx, epistaxis, rhinitis, arrhythmia, sinusitis. 
Injection site reaction, alopecia, rash, dry skin or pruritus. 
Conjunctivitis, menstrual irregularity, visual disturbances. 
Coughing, dyspnoea. 
Myalgia, joint or bone pain, arthritis or polyarthritis. 
Bone marrow depression.

Drug Dose Information

Adult: SC Renal cell carcinoma In an escalating dose of 3 million u 3 times/wk for 1 wk, then 9 million u 3 times/wk for 1 wk, then 18 million u 3 times/wk thereafter for 3-12 month.

Chronic hepatitis B 2.5-5 million u/m2 3 times/ wk for 4-6 month. 

Chronic hepatitis C W/ ribavirin: 3-4.5 million u 3 times/ week for 6 month. Monotherapy: 3 million u 3 times/week for 12 month. Hairy cell leukaemia 3 million u/day for 16-24 week

AIDS related Kaposi's sarcoma In an escalating dose of 3 million u/day for 3 days, 9 million u/day for 3 days, 18 million u/day for 3 days, and 36 million u/day (if tolerated) on days 10-84. thereafter max tolerated dose (up to 36 million u) 3 times/week.

Chronic myeloid leukaemia in an escalating dose of 3 million u/day for 3 days, 6 million u/day for 3 days, and 9 million u/day thereafter. For responders after 12 wk: Continue treatment until haematological response is complete or up to 18 mth.

Precautions

History of depression 
Seizure disorders and/or compromised CNS function. 
Preexisting or any history of cardiac disease. 
Monitor CBC prior to and during therapy. 
Myelosuppression or concurrent use of myelosuppressive drugs. 
Hypothyroidism, hyperthyroidism, DM. 
Perform ophthalmological exam on patients with preexisting ophthalmologic disorders 
Pregnancy and Lactation

Brand Information

Brand Name	ZAVINEX
Contains	interferon alfa-2a
Manufacturer Name	Zydus Cadila (Alidac Division)

Brand Specifications
	Unit	Quantity	Price	Type
1	3MIU	1	998.0300	Injection
2	5MIU	1	1498.0300	Injection

How To Take

It available as a solution for injection, to be administered either under the skin or into the muscle by a healthcare provider.

Storage

Injection: Store in a refrigerator at 2-8°C. Do not freeze it.

Contra Indications

Hypersensitivity Autoimmune hepatitis Hepatic decompensation

Reduces clearance of theophylline. Enhanced myelosuppression with other myelosuppressive drugs (e.g. zidovudine). Drugs metabolised by CYP450 pathway (monitor for changes in pharmacologic or adverse effects of concomitant drug). Increased risk of toxicity of centrally acting drugs. Increased risk of renal failure with interleukin-2.

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drug’s Side effects

It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.

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brand name : ZAVINEX

Generic name : Interferon Alfa-2a

Basic Info

Use of Drug

Category Of Drug

Side Effects

Drug Dose Information

Precautions

Brand Information

How To Take

Storage

Contra Indications

Diseases

Interactions

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brand name : ZAVINEX

Generic name : Interferon Alfa-2a

Basic Info

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