ZYROMET SR TABLET
Metformin500 mg
Aarey Drugs & Pharmaceuticals Ltd
It is available as a tablet taken orally, with food.
Store protected from light and moisture.
Renal impairment (withdraw if renal impairment suspected withdraw if tissue hypoxia likely (for example sepsis, respiratory failure, recent myocardial infarction, hepatic impairment) Use of iodine-containing X-ray contrast media (do not restart metformin until renal function returns to normal) and use of general anaesthesia (suspend metformin 2 days beforehand and restart when renal function returns to normal) Alcohol dependence Pregnancy Anaemia Ketosis
Hypotension (Low Blood Pressure) : Hypotension, also referred to as Low Blood Pressure. Low blood pressure occurs when blood pressure is much lower than normal. This means the heart, brain, and other parts of the body do not get enough blood. Normal blood pressure is usually between 90/60 mmHg and 130/80 mmHg. Certain medicines and substances can lead to low blood pressure, including: • Alcohol • Anti-anxiety medicines • Certain antidepressants • Diuretics • Heart medicines, including those used to treat high blood pressure and coronary heart disease • Medicines used for surgery • Painkillers Other causes of low blood pressure include: • Nerve damage from diabetes • Changes in heart rhythm (arrhythmias) • Not drinking enough fluids (dehydration) • Heart failure Symptoms Symptoms of low blood pressure may include: • Blurry vision • Confusion • Dizziness • Fainting (syncope) • Lightheadedness • Nausea or vomiting • Sleepiness • Weakness Treatment • Use more salt. • Drink more water. Fluids increase blood volume and help prevent dehydration, both of which are important in treating hypotension. • Wear compression stockings. The same elastic stockings commonly used to relieve the pain and swelling of varicose veins may help reduce the pooling of blood in your legs. • Medications. Several medications, either used alone or together, can be used to treat low blood pressure that occurs when you stand up (orthostatic hypotension). The drug fludrocortisone is often used to treat this form of low blood pressure.
Additive effect with sulphonylureas. Glycaemic control may be affected by diuretics, corticosteroids, phenothiazines, thyroid products, oestrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, chlorpromazine and isoniazid. Metformin effects may be increased by ACE inhibitors, disopyramide, MAOIs. Cimetidine may increase the serum levels of metformin. Concurrent use with contrast agents may increase the risk of metformin-induced lactic acidosis. May decrease the anticoagulant effect of phenprocoumon, therefore routine anticoagulant monitoring is recommended. Potentially fatal: Lactic acidosis with alcohol. Thrombocytopenia has been reported with ketotifen.
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It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.