Psoriasis : Psoriasis a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate. Environmental, genetic, and immunologic factors appear to play a role. The disease most commonly manifests on the skin of the elbows, knees, scalp, lumbosacral areas, intergluteal clefts, and glans penis. In up to 30% of patients, the joints are also affected.
Medications used in the management of psoriasis include Topical corticosteroids (eg, triamcinolone acetonide 0.025-0.1% cream, betamethasone 0.025-0.1% cream), Ophthalmic corticosteroids (eg, prednisolone acetate 1% ophthalmic, dexamethasone ophthalmic), Intramuscular corticosteroids (eg, triamcinolone). Coal tar ,Keratolytic agents (eg, anthralin), Vitamin D analogs (eg, calcitriol ointment, calcipotriene, calcipotriene and betamethasone topical ointment) and Topical retinoids (eg, tazarotene aqueous gel and cream 0.05% and 0.1%) are frequently used in the management of Psoriasis. Other choices include Antimetabolites (eg, methotrexate), Immunomodulators (eg, tacrolimus topical 0.1%, cyclosporine, alefacept, ustekinumab), TNF inhibitors (eg, infliximab, etanercept, adalimumab) and Systemic antipsoriatic agents. (eg, ustekinumab)
Human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS) : Human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS) is a disease of the human immune system caused by infection with human immunodeficiency virus (HIV).
Management
There is currently no cure or effective HIV vaccine. Treatment consists of high active antiretroviral therapy (HAART) which slows progression of the disease.
Antiviral therapy)
Current HAART options are combinations (or "cocktails") consisting of at least three medications belonging to at least two types, or "classes," of antiretroviral agents. Initially treatment is typically a non-nucleoside reverse transcriptase inhibitor (NNRTI) plus two nucleoside analogue reverse transcriptase inhibitors (NRTIs).Typical NRTIs include: zidovudine (AZT) or tenofovir (TDF) and lamivudine (3TC) or emtricitabine (FTC).Combinations of agents which include a protease inhibitors (PI) are used if the above regimen loses effectiveness