DEPSONIL
imipramine
Abbott Healthcare Pvt Ltd (Ahpl)
It is available as a tablet and capsule taken orally, with or without food.
Store it at room temperature (20° to 25°C), and in an airtight container. Keep away from children.
Recent myocardial infarction Arrhythmias (particularly heart block) Not indicated in manic phase Severe liver disease Epilepsy Mania Narrow angle glaucoma Hypersensitivity
Alzheimer's disease : Alzheimer's disease is a neurological disorder in which the death of brain cells causes memory loss and cognitive decline. A neurodegenerative type of dementia, the disease starts mild and gets progressively worse. And it is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death. Drugs has too little role in the management of Alzheimer’s disease No medication has been clearly shown to delay or halt the progression of the disease. Drugs used are • Acetylcholinesterase inhibitors – Donepezil, Galantamine, Rivastigmine • NMDA-receptor (N-Methyl-D-aspartate receptor) antagonist -Memantine Parkinson's disease : Parkinson's disease (PD also known as idiopathic or primary Parkinsonism, hypokinetic rigid syndrome/HRS, or paralysis agitans) is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain; the cause of this cell death is unknown. Tremor, rigidity, bradykinesia, and postural instability are the cardinal features of Parkinsonism and may be present in any combination. There may also be a mild decline in intellectual function. The tremor of about four to six cycles per second is most conspicuous at rest, is enhanced by emotional stress, and is often less severe during voluntary activity. Although it may ultimately be present in all limbs, the tremor is commonly confined to one limb or to the limbs on one side for months or years before it becomes more generalized. Commonly used drugs in Parkinson disease include Levodopa-Carbidopa combination, Anticholinergics (orphenadrine , procyclidine ,trihexyphenidyl ), Dopamine Agonists( Bromocriptine, Carbergoline, Ropinirole, Pramipexole and Lisuride.), COMT inhibitors (entacapone ,Tolcapone) and MAO-B inhibitors ( rasagiline,selegiline) Glaucoma : Glaucoma is a term describing a group of ocular disorders with multi-factorial etiology united by a clinically characteristic intraocular pressure-associated optic neuropathy. Treatment 1Balance and postural control 2Medications • Prostaglandin analogs, latanoprost ,bimatoprost and travoprost . • Topical beta-adrenergic receptor antagonists, such as timolol, levobunolol and betaxolol. • Alpha2-adrenergic agonists, such as brimonidine and apraclonidine. • Less-selective alpha agonists, such as epinephrine. • Miotic agents (parasympathomimetics), such as pilocarpine.Echothiophate, an acetylcholinesterase inhibitor, is used in chronic glaucoma. • Carbonic anhydrase inhibitors, such as dorzolamide , brinzolamide ,and acetazolamide . • Physostigmine
Increased plasma levels and effects with quinidine, cimetidine, SSRIs, propafenone, flecainide. Reduced plasma levels with barbiturates, phenytoin. May increase effects of anticholinergic drugs. Severe orthostatic hypotension with altretamine. Causes drowsiness and impaired performance in combination with alcohol. Severe hypertension with adrenaline, noradrenaline and methylphenidate. Reduces hypotensive effects of guanethidine, bethanidine, debrisoquine, bretylium, methyldopa and clonidine. Possible serotonin syndrome with MAOIs, separate admin by 3 week.
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It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.