SYMBAL 40mg
Duloxetine
Torrent Pharmaceuticals Ltd
Itis available as a capsule taken orally. It is usually taken once or twice a day with or without food.
Store at 25°C. Store it in air tight container and keep away from children.
Hypersensitivity Uncontrolled narrow-angle glaucoma. Concomitant use or within 2 wk of MAOIs Renal and hepatic impairment.
Peptic ulcer disease : A peptic ulcer is a defect in the lining of the stomach or the first part of the small intestine, an area called the duodenum.A peptic ulcer in the stomach is called a gastric ulcer. An ulcer in the duodenum is called a duodenal ulcer. Major causes of Peptic ulcer disease(PUD) are Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs (NSAIDs), especially in patients with risk factors such as smoking and alcohol use. Diagnostic testing for PUD includes procedures used to document the presence of an ulcer, usually endoscopy, and tests that document the presence of H. pylori infection. Eradication of H. pylori, involving the use of at least two antibiotics and a proton-pump inhibitor (PPI) for 10 to 14 days, plays a major role in curing PUD. Antibiotics to treat PUD include clarithromycin , amoxicillin, tetracycline, or metronidazole. Proton pump inhibitors (omeprazole, lansoprazole or esomeprazole), bismuth subsalicylate and ulcer protectants( sucralfate) are the other mainstays in PUD treatment. Miscarriage : Miscarriage also called Spontaneous abortion. A miscarriage is the loss of pregnancy from natural causes before the 20th week of pregnancy. Most miscarriages occur very early in the pregnancy, often before a woman even knows she is pregnant. There are many different causes for a miscarriage. Factors that may contribute to miscarriage include • A genetic problem with the fetus. This is the most common cause in the first trimester. • Problems with the uterus or cervix. These contribute in the second trimester. • Polycystic ovary syndrome Signs of a miscarriage can include vaginal spotting or bleeding, abdominal pain or cramping, and fluid or tissue passing from the vagina. Although vaginal bleeding is a common symptom of miscarriage, many women have spotting early in their pregnancy but do not miscarry. Symptoms Possible symptoms include: • Low back pain or abdominal pain that is dull, sharp, or cramping • Tissue or clot-like material that passes from the vagina • Vaginal bleeding, with or without abdominal cramps Treatment When a miscarriage occurs, the tissue passed from the vagina should be examined. This is done to determine if it was a normal placenta or a hydatidiform mole. If the pregnancy tissue does not naturally leave the body, the woman may be closely watched for up to 2 weeks. Surgery (D and C) or medication (such as misoprostol) may be needed to remove the remaining contents from the womb. After treatment, the woman usually resumes her normal menstrual cycle within 4 - 6 weeks. Any further vaginal bleeding should be carefully monitored. It is often possible to become pregnant immediately. It is recommended that women wait one normal menstrual cycle before trying to become pregnant again.
Increased risk of hepatic toxicity in patients with substantial alcohol use. Increased risk of serotonin syndrome when used with 5HT1 receptor agonists, MAOIs, lithium, tramadol or St John's wort. Avoid concurrent use with drugs that inhibit hepatic enzymes CYP1A2 and CYP2D6. Anticoagulants: May increase bleeding risk. Drugsthat reduce gastric acidity: May cause premature breakdown of duloxetin's protective coating and erly release of the drugs.
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It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.