DOMADOL
Tramadol
Unichem Laboratories Ltd
It available as a tablet, capsule taken orally with or without food. It is available as a solution for injection to be administered by a healthcare provider into the vein or large muscle.
Store it at room temperature (25°C).
Patients with suicidal tendency Raised intracranial pressure Severe renal impairment Acute alcoholism Lactation
Multiple myeloma : Multiple myeloma, also known as myeloma, plasma cell myeloma or Kahler's disease , is a hematologic cancer, or cancer of the blood. It is the second most common blood cancer, after non-Hodgkin’s lymphoma. In multiple myeloma, a certain kind of white blood cell called a plasma cell begins to multiply abnormally within the bone marrow. Normally, plasma cells are responsible for producing antibodies that help fight infections. In multiple myeloma, however, excessive plasma cells release unhealthy levels of protein (called immunoglobulin) into the bones and blood. The excessive protein accumulates throughout the body, causing organ damage. The plasma cells also cause problems inside bones, where they multiply and crowd out normal blood cells. Inside the bone marrow, multiple myeloma plasma cells release chemicals that prompt the body to dissolve areas of bone. This creates weak areas of bone, which are called lytic lesions. symptoms As multiple myeloma progresses, plasma cells accumulate in the bones, causing these symptoms: • Bone pain due to lytic bone disease • Weakness and fatigue due to anemia • Weight loss • Confusion, excessive thirst, constipation due to hypercalcemia • Kidney problems • Infections due to non-functioning immunoglobulins. Medication To treat multiple myeloma, doctors generally use a combination of chemotherapy and other drugs, which may include: • Adriamycin (doxorubicin) • Alkeran (melphalan) • Cytoxan (cyclophosphamide) • Oncovin (vincristine) • Pomalyst (pomalidomide) • Revlimid (lenalidomide) • Thalomid (thalidomide) • Velcade (bortezomib) Doctors can choose from multiple combinations of chemotherapy drugs. Corticosteroids (such as prednisone or dexamethasone) are often given with chemotherapy, to reduce side effects. Interferon is a hormone-like drug that can help keep multiple myeloma in remission after chemotherapy.
Alcohol (Ethanol) Moderate Drug Interaction Reduced analgesic efficacy of tramadol with carbamezapine,5-HT3 receptor antagonist eg:Ondansetron Possible increase in anticoagulation with warfarin Antidepressants SSRI: increased risk of CNS toxicity when tramadol given with SSRIs. Antidepressants Tricyclic: increased risk of CNS toxicity when tramadol given with tricyclics Coumarins: tramadol enhances anticoagulant effect of coumarins Seligiline: caution with tramadol advised by manufacturer of selegiline.
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It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.