PHENYKEM 30MG SUSPENSION
Phenytoin30 mg
Alkem Laboratories
Phenytoin is available as extended-release (long-acting) capsule, a chewable tablet, and a suspension (liquid) orally. The chewable tablet and suspension are usually taken two or three times a day. Phenytoin should be taken with food. When administering to patients on nasogastric or other enteral feeds, do not administer feeds 2 hr before or after a dose. Be consistent throughout therapy in relation to feed times. Do not switch dosage forms/brands with out prior consideration.
Store protected from moisture at temperature not exceeding 30°C.
Porphyria Avoid parenteral use in sinus bradycardia Sino-atrial block, second- and third-degree heart block Stokes-Adams syndrome Pregnancy
Hypertension : .Glaucoma : Glaucoma is a term describing a group of ocular disorders with multi-factorial etiology united by a clinically characteristic intraocular pressure-associated optic neuropathy. Treatment 1Balance and postural control 2Medications • Prostaglandin analogs, latanoprost ,bimatoprost and travoprost . • Topical beta-adrenergic receptor antagonists, such as timolol, levobunolol and betaxolol. • Alpha2-adrenergic agonists, such as brimonidine and apraclonidine. • Less-selective alpha agonists, such as epinephrine. • Miotic agents (parasympathomimetics), such as pilocarpine.Echothiophate, an acetylcholinesterase inhibitor, is used in chronic glaucoma. • Carbonic anhydrase inhibitors, such as dorzolamide , brinzolamide ,and acetazolamide . • Physostigmine
Effects with other sedative drugs or ethanol may be potentiated. Enhances toxic effects of paracetamol, lithium. Increased risk of osteomalacia with acetazolamide. Decreased serum levels/effects with acyclovir, antineoplastics, benzodiazeines, ciprofloxacin, CYP2C9 inducers (e.g. carbamazepine), CYP2C19 inducers (e.g. rifampin), folic acid, vigabatrin. Increased serum concentrations with allopurinol, capecitabine, cimetidine, CYP2C9 inhibitors (e.g. fluconazole), CYP2C19 inhibitors (e.g. delavirdine), disulfiram, methylphenidate, metronidazole, omeprazole, SSRI, trazodone, trimethoprim. Increases metabolism of antiarrhythmics, anticonvulsants, antipsychotics, beta-blockers, calcium channel blockers, chloramphenicol, corticosteroids, doxycycline, oestrogens, HMG-CoA reductase inhibitors, methadone, theophylline, TCAs. Decreases levels/effects of clozapine, ciclosporin, tacrolimus, CYP2B6 substrates (e.g. bupropion, selegiline), CYP2C8 substrates (e.g. amiodarone).
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It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.