PHENTOIN 100MG TABLET
Phenytoin 100 mg
Reliance Formulation
Phenytoin is available as extended-release (long-acting) capsule, a chewable tablet, and a suspension (liquid) orally. The chewable tablet and suspension are usually taken two or three times a day. Phenytoin should be taken with food. When administering to patients on nasogastric or other enteral feeds, do not administer feeds 2 hr before or after a dose. Be consistent throughout therapy in relation to feed times. Do not switch dosage forms/brands with out prior consideration.
Store protected from moisture at temperature not exceeding 30°C.
Porphyria Avoid parenteral use in sinus bradycardia Sino-atrial block, second- and third-degree heart block Stokes-Adams syndrome Pregnancy
Acne vulgaris : Acne vulgaris (or simply acne) is a common human skin disease, characterized by areas of skin with seborrhea (scaly red skin), comedones (blackheads and whiteheads), papules (pinheads), nodules (large papules), pimples, and possibly scarring. Acne affects mostly skin with the densest population of sebaceous follicles; these areas include the face, the upper part of the chest, and the back. Treatment - Treatment of acne should be commenced early to prevent scarring. Patients should be counselled that an improvement may not be seen for at least a couple of months. The choice of treatment depends on whether the acne is predominantly inflammatory or comedonal and its severity. (1) Mild to moderate acne is generally treated with topical preparations such as topical retinoids ( Tretinoin and Isotretinoin),Adapalene, Benzoyl peroxide, Azelaic acid,Salicylic acid, Erythromycin and Clindamycin (2) Severe acne is generally treated with Oral antibiotics such as oxytetracycline or tetracycline,Erythromycin,Trimethoprim, Doxycycline and minocycline (3) Hormone treatment - Cyproterone acetate with ethinylestradiol (4) Oral retinoid for acne -Iisotretinoin Skin infections : .
Effects with other sedative drugs or ethanol may be potentiated. Enhances toxic effects of paracetamol, lithium. Increased risk of osteomalacia with acetazolamide. Decreased serum levels/effects with acyclovir, antineoplastics, benzodiazeines, ciprofloxacin, CYP2C9 inducers (e.g. carbamazepine), CYP2C19 inducers (e.g. rifampin), folic acid, vigabatrin. Increased serum concentrations with allopurinol, capecitabine, cimetidine, CYP2C9 inhibitors (e.g. fluconazole), CYP2C19 inhibitors (e.g. delavirdine), disulfiram, methylphenidate, metronidazole, omeprazole, SSRI, trazodone, trimethoprim. Increases metabolism of antiarrhythmics, anticonvulsants, antipsychotics, beta-blockers, calcium channel blockers, chloramphenicol, corticosteroids, doxycycline, oestrogens, HMG-CoA reductase inhibitors, methadone, theophylline, TCAs. Decreases levels/effects of clozapine, ciclosporin, tacrolimus, CYP2B6 substrates (e.g. bupropion, selegiline), CYP2C8 substrates (e.g. amiodarone).
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It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.